Artificial Intelligence LifeMine Therapeutics | Reinventing Drug Discovery


LifeMine Therapeutics

Artificial Intelligence


LifeMine Therapeutics | Reinventing Drug Discovery

LifeMine Therapeutics


LifeMine Therapeutics is reinventing drug discovery by mining genetically-encoded small molecules (GEMs) from the biosphere. Through its proprietary, evolutionarily-derived genomic drug discovery platform, LifeMine aims to bring unparalleled speed, predictability, and scalability to small molecule drug discovery. lifeMine has discovered, in genomic space, hundreds of potentially high-impact drug candidates relevant to targets across all major disease areas, and has an initial focus on advancing highly impactful precision medicines in oncology and immune modulation.

LifeMine has amassed a virtually limitless amount of natural biological space to digitally search for new drugs – consisting of a fully curated fungal genome repository of an unprecedented scale. Given their evolutionary proximity to humans, fungi have long been an important source of radically impactful medicines. Drugs derived from fungi often target the same protein in fungi and humans – in fact, fungi are prodigious manufacturers of genetically-encoded small molecules (GEMs) that engage human targets. As such, fungi act as “avatars” to find small molecule therapeutic solutions for human diseases. But discovering these GEMs has heretofore been fraught with difficulty, leaving the precious GEMs just beyond reach. Enter LifeMine, with an entirely new way to discover GEMs, by searching for them algorithmically in genomic space rather than physically in chemical space.

LifeMine’s Avatar-Rx platform seamlessly integrates high-throughput microbiology, data science and machine learning, genome engineering, and automation technologies to search the fungal biosphere for novel GEMs having a predetermined target and biological function. Downstream of GEM discovery, LifeMine’s platform further integrates chemoinformatic-assisted drug optimization and state-of-the-art chemical synthesis with biotransformation to advance new product candidates into developme

 

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